Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer

BackgroundSpread through air spaces (STAS) represents a novel invasion mechanism in adenocarcinoma that considerably influences lung cancer clinical outcomes; however, studies of its mechanisms at the spatial level are lacking.MethodsWe used the NanoString GeoMx digital spatial profiling (DSP) techn...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Wenhao Wang, Wenhao Zhou, Jingli Fan, Tao Jiang, Guang Yang, Congcong Song, Siwei Xu, Haitao Luo, Huining Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	spread through air spaces non-small-cell lung cancer digital spatial profiling spatial heterogeneity spatial transcriptome
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1567527/full