Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS

NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death. In diseases characterized by non-cell autonomous neurodegeneration including amyotrophic lateral...

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發表在:	Frontiers in Immunology
Main Authors:	Marie-Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S. Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadiu
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2023-07-01
主題:	NLRP1 NLRP3 NLRC4 MEFV inflammasomes iPSC-derived microglia
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190219/full