CD8+ T cells in breast cancer tumors and draining lymph nodes: PD-1 levels, effector functions and prognostic relevance

CD8+ T cells shape the antitumor immune response. Here, we evaluated CD8+ T cells expressing different levels of PD-1, their functional status, and distribution in different tissues of luminal breast cancer (BC) patients. We characterized the exhaustion stages of CD8+ T cells in tumors, juxtatumoral...

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Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Carolina Abrate, Fernando P. Canale, Sabrina N. Bossio, Jimena Tosello Boari, María C. Ramello, Nicolas Nuñez, Wilfrid Richer, Christine Sedlik, Jordan Denizeau, Anne Vincent-Salomon, Edith Borcoman, Andres Del Castillo, Adriana Gruppi, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Breast cancer CD8+ T cells exhaustion PD-1 draining lymph nodes
Online Access:	https://www.tandfonline.com/doi/10.1080/2162402X.2025.2502354