Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor

Bone homeostasis is maintained by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. A dramatic decrease in estrogen levels in postmenopausal women leads to osteoclast overactivation, impaired bone homeostasis, and subsequent bone loss. Changes in the gut microbiome affect b...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Renpeng Peng, Chao Song, Shuangquan Gou, Haiyang Liu, Honglei Kang, Yimin Dong, Yong Xu, Peixuan Hu, Kaiyong Cai, Qian Feng, Hanfeng Guan, Feng Li
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Subjects:	Gut microbiota Clostridium sporogenes Indole propionic acid Osteoclast Pregnane X receptor
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661824000653