Human Small Intestinal Tissue Models to Assess Barrier Permeability: Comparative Analysis of Caco-2 Cells, Jejunal and Duodenal Enteroid-Derived Cells, and EpiIntestinal^TM Tissues in Membrane-Based Cultures with and Without Flow

Accurate in vitro models of intestinal permeability are essential for predicting oral drug absorption. Standard models like Caco-2 cells have well-known limitations, including lack of segment-specific physiology, but are widely used. Emerging models such as organoid-derived monolayers and microphysi...

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Bibliographic Details

Published in:	Bioengineering
Main Authors:	Haley L. Moyer, Leoncio Vergara, Clifford Stephan, Courtney Sakolish, Hsing-Chieh Lin, Weihsueh A. Chiu, Remi Villenave, Philip Hewitt, Stephen S. Ferguson, Ivan Rusyn
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Subjects:	tissue chip bioavailability new approach methods
Online Access:	https://www.mdpi.com/2306-5354/12/8/809