Two Birds with One Stone: A Novel Dithiomaleimide-Based GalNAc-siRNA Conjugate Enabling Good siRNA Delivery and Traceability

For the first time, a novel dithiomaleimides (DTM) based tetra-antennary GalNAc conjugate was developed, which enable both efficient siRNA delivery and good traceability, without incorporating extra fluorophores. This conjugate can be readily constructed by three click-type reactions, that is, amida...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Sudong Kong, Xiaoqing Gao, Qianhui Wang, Jianguo Lin, Ling Qiu, Minhao Xie
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Subjects:	GalNAc-siRNA conjugate siRNA delivery dithiomaleimides click chemistry
Online Access:	https://www.mdpi.com/1420-3049/28/20/7184