<i>Bis</i>(Tryptophan) Amphiphiles Form Ion Conducting Pores and Enhance Antimicrobial Activity against Resistant Bacteria

The compounds referred to as <i>bis</i>(tryptophan)s (BTs) have shown activity as antimicrobials. The hypothesis that the activity of these novel amphiphiles results from insertion in bilayer membranes and transport of cations is supported by planar bilayer voltage-clamp studies reported...

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Bibliographic Details

Published in:	Antibiotics
Main Authors:	Mohit Patel, Saeedeh Negin, Joseph Meisel, Shanheng Yin, Michael Gokel, Hannah Gill, George Gokel
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	adjuvant amino acids amphiphile antimicrobial bacteria efflux pump
Online Access:	https://www.mdpi.com/2079-6382/10/11/1391