Pancreatic enzyme supplementation versus placebo for improvement of gastrointestinal symptoms in non-responsive celiac disease: A cross-over randomized controlled trial

BackgroundPancreatic Exocrine Insufficiency (PEI) is a possible cause of recurrent/persistent symptoms in celiac disease. Although pancreatic enzyme supplementation may be used to treat non-responsive celiac disease (NRCD) in clinical practice, clinical outcomes are variable and there is limited and...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Shakira Yoosuf, Caitlin G. Barrett, Konstantinos Papamichael, Sarah E. Madoff, Satya Kurada, Joshua Hansen, Jocelyn A. Silvester, Amelie Therrien, Prashant Singh, Melinda Dennis, Daniel A. Leffler, Ciaran P. Kelly
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	diarrhea sprue malabsorption exocrine pancreatic insufficiency proton pump inhibitors pancreas
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2022.1001879/full