The Role of AMPKα in the Mechanism of Development and Treatment of Heart Failure

The AMP-activated protein kinase (AMPK) alpha (AMPKα) subunit is the catalytic subunit in the AMPK complex and includes both α1 and α2 isoforms. Phosphorylation of upstream kinases at the Thr172 site in the α-subunit is critical for AMPK activation. The kinases upstream of AMPK include liver kinase...

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Bibliographic Details

Published in:	Reviews in Cardiovascular Medicine
Main Authors:	Yue Feng, Zixiong Zhu, Yubin He, Xuewen Li
Format:	Article
Language:	English
Published:	IMR Press 2025-08-01
Subjects:	ampkα heart failure energy metabolism mitochondrial dysfunction autophagy oxidative stress ampk agonists
Online Access:	https://www.imrpress.com/journal/RCM/26/8/10.31083/RCM36391