The STC2–PAPP-A–IGFBP4–IGF1 axis and its associations to mortality and CVD in T2D

Objective: Physiologically, pregnancy-associated plasma protein-A (PAPP-A) serves to liberate bound IGF1 by enzymatic cleavage of IGF-binding proteins (IGFBPs), IGFBP4 in particular. Clinically, PAPP-A has been linked to cardiovascular disease (CVD). Stanniocalcin-2 (STC2) is a natural inhibitor...

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Bibliographic Details

Published in:	Endocrine Connections
Main Authors:	Mette Faurholdt Gude, Rikke Hjortebjerg, Mette Bjerre, Morten Haaning Charles, Daniel R Witte, Annelli Sandbæk, Jan Frystyk
Format:	Article
Language:	English
Published:	Bioscientifica 2023-02-01
Subjects:	stanniocalcin-2 papp-a igfbp4 igf1 cardiovascular disease type 2 diabetes
Online Access:	https://ec.bioscientifica.com/view/journals/ec/12/3/EC-22-0451.xml