Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma

Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with the development of hypermutant pediatric high-grade glioma, and confers a poor prognosis. While therapeutic histone deacetylase (HDAC) inhibition of diffuse intrinsic pontine glioma (DIPG) has been...

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Bibliographic Details

Published in:	Neoplasia: An International Journal for Oncology Research
Main Authors:	Alyssa Noll, Carrie Myers, Matthew C. Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E. Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E.S. Leary, Bonnie L. Cole, Evangeline R. Jackson, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, James M. Olson, Nicholas A. Vitanza
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Subjects:	Diffuse intrinsic pontine glioma (DIPG) Hypermutant Mismatch-repair (MMR) Histone deacetylase inhibitor (HDACi) Quisinostat
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558623000465