Serum anti-PAD4 autoantibodies are present in cystic fibrosis children and increase with age and lung disease severity

Cystic fibrosis (CF) lung disease begins early in childhood and is characterized by neutrophilic inflammation of the airways. Neutrophil extracellular traps (NETs) represent one mechanism by which neutrophils contribute to lung damage. The enzyme peptidylarginine deiminase 4 (PAD4) is required for N...

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Bibliographic Details

Published in:	Autoimmunity
Main Authors:	Rachel W. Linnemann, Ruchi Yadav, Chao Zhang, Demba Sarr, Balázs Rada, Arlene A. Stecenko
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-02-01
Subjects:	cystic fibrosis autoimmunity autoantibody neutrophils neutrophil extracellular traps
Online Access:	http://dx.doi.org/10.1080/08916934.2021.2021193