Immunoglobulin Fc heterodimer platform technology: From design to applications in therapeutic antibodies and proteins

The monospecific and bivalent characteristics of naturally occurring immunoglobulin G (IgG) antibodies depend on homodimerization of the fragment crystallizable (Fc) regions of two identical heavy chains (HCs) and the subsequent assembly of two identical light chains (LCs) via disulfide linkages bet...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Ji-Hee Ha, Jung-Eun Kim, Yong-Sung Kim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-10-01
Subjects:	Antibody engineering bispecific antibody Fc engineering immunocytokines Fc-fusion proteins heterodimeric Fc
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00394/full