Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

Human immune system (HIS) mice constructed in various ways are widely used for investigations of human immune responses to pathogens, transplants, and immunotherapies. In HIS mice that generate T cells de novo from hematopoietic progenitors, T cell-dependent multisystem autoimmune disease occurs, mo...

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Bibliographic Details

Published in:	eLife
Main Authors:	Mohsen Khosravi-Maharlooei, Andrea Vecchione, Nichole Danzl, Hao Wei Li, Grace Nauman, Rachel Madley, Elizabeth Waffarn, Robert Winchester, Amanda Ruiz, Xiaolan Ding, Georgia Fousteri, Megan Sykes
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-04-01
Subjects:	T follicular helper cell human immune system T peripheral helper cell T cells autoimmunity B cells
Online Access:	https://elifesciences.org/articles/99389