Lipid metabolism in ferroptosis: mechanistic insights and therapeutic potential

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, plays a pivotal role in various physiological and pathological processes. In this review, we summarize the core mechanisms of ferroptosis, emphasizing its intricate connections to lipid metabolism, including fa...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Daoyun Sun, Longfei Wang, Yufan Wu, Yi Yu, Yufeng Yao, Hongju Yang, Chunlin Hao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	ferroptosis lipid peroxidation iron metabolism antioxidant defense therapeutic targeting
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1545339/full