A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction

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We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212–2 intravenous self-administration (0.0125 mg/kg/infusion) in C57Bl/6J mice. This model allows to evaluate the addiction criteria by grouping them into 1) persistence of response during a period of non-avai...

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Bibliographic Details
Published in:Frontiers in Pharmacology
Main Authors: María del Mar Cajiao-Manrique, Rafael Maldonado, Elena Martín-García
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Subjects:
cannabinoid addiction
mouse model
WIN 55,212-2 self-administration
persistence of response
motivation
compulsive-like behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1143365/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1143365/full

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