Exceptional response to lurbinectedin and irinotecan in -mutated platinum-resistant ovarian cancer patient: a case report

Lurbinectedin is responsible for DNA recognition and binding, producing double-strand DNA (dsDNA) breaks thus resulting in apoptosis. Sensitivity to lurbinectedin is linked to the nucleotide excision repair (NER) system. Furthermore, irinotecan, a topoisomerase I inhibitor, provokes dsDNA breaks tha...

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Bibliographic Details

Published in:	Therapeutic Advances in Chronic Disease
Main Authors:	Laura Cortesi, Marta Venturelli, Elena Barbieri, Cinzia Baldessari, Camilla Bardasi, Emanuele Coccia, Federica Baglio, Margherita Rimini, Stefano Greco, Martina Napolitano, Stefania Pipitone, Massimo Dominici
Format:	Article
Language:	English
Published:	SAGE Publishing 2022-01-01
Online Access:	https://doi.org/10.1177/20406223211063023