Detection of circular permutations by Protein Language Models

Protein circular permutations are crucial for understanding protein evolution and functionality. Traditional detection methods face challenges: sequence-based approaches struggle with detecting distant homologs, while structure-based approaches are limited by the need for structure generation and of...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Yue Hu, Bin Huang, Chun Zi Zang, Jia Jie Xu
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Circular Permutation； Protein Language Models； Protein Structure Alignment
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037024004525