Bone Morphogenetic Protein 2 (BMP-2) Aggregates Can be Solubilized by Albumin—Investigation of BMP-2 Aggregation by Light Scattering and Electrophoresis

Bone morphogenetic protein 2 (BMP-2) has a high tendency to aggregate at physiological pH and physiological ionic strength, which can complicate the development of growth factor delivery systems. The aggregation behavior in differently concentrated BMP-2 solutions was investigated using dynamic and...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Julius Sundermann, Holger Zagst, Judith Kuntsche, Hermann Wätzig, Heike Bunjes
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	BMP-2 albumin protein aggregation protein-protein interactions protein solubilization
Online Access:	https://www.mdpi.com/1999-4923/12/12/1143