Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides

Abstract Alzheimer’s disease (AD) is the most common cause of dementia worldwide. AD brains display deposits of insoluble amyloid plaques consisting mainly of aggregated amyloid-β (Aβ) peptides, and Aβ oligomers are likely a toxic species in AD pathology. AD patients display altered metal homeostasi...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Elina Berntsson, Faraz Vosough, Teodor Svantesson, Jonathan Pansieri, Igor A. Iashchishyn, Lucija Ostojić, Xiaolin Dong, Suman Paul, Jüri Jarvet, Per M. Roos, Andreas Barth, Ludmilla A. Morozova-Roche, Astrid Gräslund, Sebastian K. T. S. Wärmländer
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-02-01
Online Access:	https://doi.org/10.1038/s41598-023-29901-5