Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling.

We have previously demonstrated the role of gastrin-releasing peptide (GRP) as an autocrine growth factor for neuroblastoma. Here, we report that GRP silencing regulates cell signaling involved in the invasion-metastasis cascade. Using a doxycycline inducible system, we demonstrate that GRP silencin...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Pritha Paul, Jingbo Qiao, Kwang Woon Kim, Carmelle Romain, Sora Lee, Natasha Volny, Bret Mobley, Hernan Correa, Dai H Chung
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	http://europepmc.org/articles/PMC3767701?pdf=render