The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance
Opioids remain among the most effective pain-relieving therapeutics. However, their long-term use is limited due to the development of tolerance and potential for addiction. For many years, researchers have explored the underlying mechanisms that lead to this decreased effectiveness of opioids after...
| Published in: | Frontiers in Neuroscience |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-11-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2018.00886/full |