Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors

IntroductionIncreased T cell infiltration and interferon gamma (IFNγ) pathway activation are seen in tumors of melanoma patients who respond to ICI (immune checkpoint inhibitor) or MAPK pathway inhibitor (MAPKi) therapies. Yet, the rate of durable tumor control after ICI is almost twice that of MAPK...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	melanoma immunotherapy checkpoint inhibitors interferon gamma pathway tertiary lymphoid structure (TLS) T cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1176994/full