Discovering monoacylglycerol lipase inhibitors by a combination of fluorogenic substrate assay and activity-based protein profiling

The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly metabolized by monoacylglycerol lipase (MAGL) in the brain. Selective inhibitors of MAGL provide valuable insights into the role of 2-AG in a variety of (patho)physiological processes and are potential therapeutics for the treatment...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Hui Deng, Qianwen Zhang, Qian Lei, Na Yang, Kai Yang, Jianbing Jiang, Zhiyi Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	monoacylglycerol lipase inhibitor discovery fluorogenic substrate assay activity-based protein profiling anticancer activity
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.941522/full