C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo

We previously demonstrated that a synthetic monomer peptide derived from the C-terminus of p53 (aa 361–382) induced preferential apoptosis in mutant p53 malignant cells, but not normal cells. The major problem with the peptide was its short half-life (half-life < 10 min.) due to a random coil top...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Robert L. Fine, Yuehua Mao, Richard Dinnen, Ramon V. Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N. Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W. Brandt-Rauf
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Subjects:	p53 p53 peptide apoptosis breast cancer Fas Bax
Online Access:	https://www.mdpi.com/2227-9059/11/1/137