Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology

Large numbers of point mutations in SQSTM1/p62 have been identified in amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). SQSTM1 interacts with ubiquitinated proteins, undergoing liquid-liquid phase separation, and the resulting SQSTM1-droplets are degraded by macroautophagy/...

Full description

Bibliographic Details

Published in:	Autophagy Reports
Main Authors:	Yoshinobu Ichimura, Masaaki Komatsu
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Subjects:	amyotrophic lateral sclerosis autophagy liquid droplet nrf2 p62
Online Access:	http://dx.doi.org/10.1080/27694127.2022.2031380