Circular RNA RORβ regulates TGFβR1 in alcohol-induced fibroblast-to-myofibroblast differentiation

Abstract Alcohol exposure augments the expression and signaling of transforming growth factor-beta (TGFβ), leading to fibroproliferation. We showed that inhibition of TGFβ receptor type 1 (TGFβR1) mitigates the effect of alcohol in the lung. We further demonstrated that alcohol modulates TGFβ signal...

Full description

Bibliographic Details
Published in:Scientific Reports
Main Authors: Viranuj Sueblinvong, Xian Fan, Harry Kartmouty-Quintana, Benjamin T. Kopp, Bum-Yong Kang
Format: Article
Language:English
Published: Nature Portfolio 2025-09-01
Subjects:
Alcohol
microRNA
Circular RNA
Circ-RORβ
TGFβ receptor 1
Fibroblast-to-myofibroblast differentiation
Online Access:https://doi.org/10.1038/s41598-025-15040-6

Internet

https://doi.org/10.1038/s41598-025-15040-6

Similar Items