Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmitophagy is altered in Alzheimer's disease (AD). Here we r...

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Bibliographic Details
Published in:Neurobiology of Disease
Main Authors: Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait, Mikko T. Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, Andrii Domanskyi, Riikka H. Hämäläinen, Gundars Goldsteins, Jari Koistinaho, Tarja Malm, Sweelin Chew, Kirsi Rilla, Anthony R. White, Nicholas Marsh-Armstrong, Katja M. Kanninen
Format: Article
Language:English
Published: Elsevier 2022-08-01
Subjects:
Alzheimer's disease
Astrocytes
Mitochondria
Mitophagy
Transmitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001450

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http://www.sciencedirect.com/science/article/pii/S0969996122001450

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