New models of Parkinson’s like neuroinflammation in human microglia clone 3: Activation profiles induced by INF-γ plus high glucose and mitochondrial inhibitors

Microglia activation and neuroinflammation have been extensively studied in murine models of neurodegenerative diseases; however, to overcome the genetic differences between species, a human cell model of microglia able to recapitulate the activation profiles described in patients is needed. Here we...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Francesca De Chirico, Eleonora Poeta, Giorgia Babini, Iliana Piccolino, Barbara Monti, Francesca Massenzio
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	human microglia HMC3 neuroinflammation Parkinson’s disease IFN-γ glucose
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2022.1038721/full