Tandem Hock and Friedel–Crafts reactions allowing an expedient synthesis of a cyclolignan-type scaffold

The Hock cleavage, which is compatible with tandem processes, was applied to the synthesis of 1-aryltetralines through a one-pot transformation from readily available benzyl(prenyl)malonate substrates. After the photooxygenation of the prenyl moiety, the resulting hydroperoxide was directly engaged...

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Bibliographic Details

Published in:	Beilstein Journal of Organic Chemistry
Main Authors:	Viktoria A. Ikonnikova, Cristina Cheibas, Oscar Gayraud, Alexandra E. Bosnidou, Nicolas Casaretto, Gilles Frison, Bastien Nay
Format:	Article
Language:	English
Published:	Beilstein-Institut 2024-01-01
Subjects:	1-aryltetralines friedel–crafts reaction hock rearrangement oxidative cleavage tandem reactions
Online Access:	https://doi.org/10.3762/bjoc.20.15