Ibrutinib Contributes to Atrial Arrhythmia through the Autophagic Degradation of Connexins by Inhibiting the PI3K-AKT-mTOR Signaling Pathway

Background: Ibrutinib could increase the risk of atrial fibrillation (AF) in chronic lymphocytic leukemia (CLL) patients. However, the precise mechanism underlying ibrutinib-induced AF remains incompletely elucidated. Methods: We investigated the proportion of ibrutinib-treated CLL patients with new...

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Bibliographic Details

Published in:	Frontiers in Bioscience-Landmark
Main Authors:	Huiyuan Qin, Bingyu Zheng, Zhiqiao Lin, Yumeng Ji, Cheng Wang, Huayuan Zhu, Chang Cui, Zidun Wang, Minglong Chen
Format:	Article
Language:	English
Published:	IMR Press 2024-05-01
Subjects:	ibrutinib atrial fibrillation connexins 43 connexins 40 autophagy
Online Access:	https://www.imrpress.com/journal/FBL/29/5/10.31083/j.fbl2905201