α1-Adrenoceptor agonist methoxamine inhibits base excision repair via inhibition of apurinic/apyrimidinic endonuclease 1 (APE1)

Methoxamine (Mox) is a well-known α1-adrenoceptor agonist, clinically used as a longer-acting analogue of epinephrine. 1R,2S-Mox (NRL001) has been also undergoing clinical testing to increase the canal resting pressure in patients with bowel incontinence. Here we show, that Mox hydrochloride acts as...

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Bibliographic Details

Published in:	Acta Pharmaceutica
Main Authors:	Kohutova Aneta, Münzova Dita, Pešl Martin, Rotrekl Vladimir
Format:	Article
Language:	English
Published:	Sciendo 2023-06-01
Subjects:	methoxamine base excision repair apurinic/apyrimidinic endonuclease ape1 α1-adrenoceptor agonist
Online Access:	https://doi.org/10.2478/acph-2023-0012