Nf1 deficiency modulates the stromal environment in the pretumorigenic rat mammary gland

Background:Neurofibromin, coded by the NF1 tumor suppressor gene, is the main negative regulator of the RAS pathway and is frequently mutated in various cancers. Women with Neurofibromatosis Type I (NF1)–a tumor predisposition syndrome caused by a germline NF1 mutation–have an increased risk of deve...

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書誌詳細

出版年:	Frontiers in Cell and Developmental Biology
主要な著者:	Menusha Arumugam, Elizabeth A. Tovar, Curt J. Essenburg, Patrick S. Dischinger, Ian Beddows, Emily Wolfrum, Zach B. Madaj, Lisa Turner, Kristin Feenstra, Kristin L. Gallik, Lorna Cohen, Madison Nichols, Rachel T. C. Sheridan, Corinne R. Esquibel, Ghassan Mouneimne, Carrie R. Graveel, Matthew R. Steensma
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2024-05-01
主題:	NF1 mammary stroma adipocyte differentiation collagen
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1375441/full