The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors

Different anandamide (AEA) transport inhibitors show antinociceptive and antiinflammatory effects in vivo, but due to their concomitant inhibition of fatty acid amide hydrolase (FAAH) and overall poor bioavailability, they cannot be used unequivocally to study the particular role of endocannabinoid...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Inés Reynoso-Moreno, Andrea Chicca, Mario E. Flores-Soto, Juan M. Viveros-Paredes, Jürg Gertsch
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Subjects:	allodynia endocannabinoids inflammation monoarthritis polypharmacology bioavailability
Online Access:	https://www.frontiersin.org/article/10.3389/fnmol.2018.00180/full