Therapeutic targeting of TP53 nonsense mutations in cancer
Mutations in the TP53 tumor suppressor gene occur with high prevalence in a wide range of human tumors. A significant fraction of these mutations (around 10%) are nonsense mutations, creating a premature termination codon (PTC) that leads to the expression of truncated inactive p53 protein. Inductio...
| Published in: | Upsala Journal of Medical Sciences |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Upsala Medical Society
2024-05-01
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| Subjects: | |
| Online Access: | https://ujms.net/index.php/ujms/article/view/10719/17305 |