Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

Summary: The G protein-coupled receptors of the Frizzled (FZD) family, in particular FZD1,2,7, are receptors that are exploited by Clostridioides difficile toxin B (TcdB), the major virulence factor responsible for pathogenesis associated with Clostridioides difficile infection. We employ a live-cel...

Full description

Bibliographic Details

Published in:	Cell Reports
Main Authors:	Julia Kinsolving, Julien Bous, Pawel Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, Geoffrey Masuyer, Yuankai Wang, Pål Stenmark, Min Dong, Gunnar Schulte
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Subjects:	CP: Molecular biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S221112472400055X