Implementation of pharmacogenetic testing in oncology: DPYD-guided dosing to prevent fluoropyrimidine toxicity in British Columbia

Background: Fluoropyrimidine toxicity is often due to variations in the gene (DPYD) encoding dihydropyrimidine dehydrogenase (DPD). DPYD genotyping can be used to adjust doses to reduce the likelihood of fluoropyrimidine toxicity while maintaining therapeutically effective drug levels.Methods: A mul...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Angela Wu, Helen Anderson, Curtis Hughesman, Sean Young, Caroline Lohrisch, Colin J. D. Ross, Bruce C. Carleton
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Subjects:	adverse drug reactions clinical implementation DPYD fluoropyrimidine toxicity pharmacogenetics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1257745/full