Accumulation of liposomes in metastatic tumor sites is not necessary for anti-cancer drug efficacy

Abstract Background The tumor microenvironment is profoundly heterogeneous particularly when comparing sites of metastases. Establishing the extent of this heterogeneity may provide guidance on how best to design lipid-based drug delivery systems to treat metastatic disease. Building on our previous...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Jessica Kalra, Jennifer Baker, XuXin Sun, Alastair Kyle, Andrew Minchinton, Marcel B. Bally
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Liposomes Enhanced permeability and retention effect Metastases/metastasis Tumor microenvironment Inter- and intra-tumor heterogeneity Pre-clinical models
Online Access:	https://doi.org/10.1186/s12967-024-05428-9