Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights

This research study describes the development of new small molecules based on 2,4-thiazolidinedione (2,4-TZD) and their aldose reductase (AR) inhibitory activities. The synthesis of 17 new derivatives of 2,4-TZDs hybrids was feasible by incorporating two known bioactive scaffolds, benzothiazole hete...

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Bibliographic Details

Published in:	Journal of Enzyme Inhibition and Medicinal Chemistry
Main Authors:	Abdelrahman Hamdi, Muhammad Yaseen, Wafaa A. Ewes, Mashooq Ahmad Bhat, Noha I. Ziedan, Hamed W. El-Shafey, Ahmed A. B. Mohamed, Mohamed R. Elnagar, Abdullah Haikal, Dina I. A. Othman, Abdullah A. Elgazar, Ahmed H. A. Abusabaa, Kamal S. Abdelrahman, Osama M. Soltan, Mostafa M. Elbadawi
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Thiazolidinone-2,4-diones benzothiazole aldose reductase inhibition antihyperglycaemic docking
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2231170