Quantification of Paeoniflorin by Fully Validated LC–MS/MS Method: Its Application to Pharmacokinetic Interaction between Paeoniflorin and Verapamil

A rapid, sensitive, and specific LC-MS/MS method was developed and fully validated for the detection of paeoniflorin only in rat plasma, and applied to pharmacokinetic studies, including intravenous, multi-dose oral and combined administrations with verapamil. In this study, tolbutamide was used as...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Bin Bao, Yonglin Zhao, Huan Gong, Songshan Shi, Huijun Wang, Shunchun Wang
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	paeoniflorin verapamil pharmacokinetic LC–MS/MS
Online Access:	https://www.mdpi.com/1420-3049/27/23/8337