Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

Local structural frustration, the existence of mutually exclusive competing interactions, may explain why some proteins are dynamic while others are rigid. Frustration is thought to underpin biomolecular recognition and the flexibility of protein-binding sites. Here, we show how a small chemical mod...

詳細記述

書誌詳細

出版年:	eLife
主要な著者:	Lukas S Stelzl, Despoina AI Mavridou, Emmanuel Saridakis, Diego Gonzalez, Andrew J Baldwin, Stuart J Ferguson, Mark SP Sansom, Christina Redfield
フォーマット:	論文
言語:	英語
出版事項:	eLife Sciences Publications Ltd 2020-06-01
主題:	local frustration NMR molecular dynamics protein dynamics oxidoreductase
オンライン･アクセス:	https://elifesciences.org/articles/54661