Neurogenic differentiation 2 promotes inflammatory activation of macrophages in doxorubicin-induced myocarditis via regulating protein kinase D

Abstract Background Although it has been established that protein kinase D (PKD) plays a crucial role in various diseases, its precise role in myocarditis remains elusive. Methods To investigate PKD’s involvement in myocarditis, we established a mouse model of myocarditis using doxorubicin (DOX) to...

Full description

Bibliographic Details

Published in:	BMC Cardiovascular Disorders
Main Authors:	Xinyu Tan, Changyu Yan, Gang Zou, Ran Jing
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Myocarditis NeuroD2 PKD Macrophages Inflammatory activation NLRP3/NF-κB pathway
Online Access:	https://doi.org/10.1186/s12872-025-04626-7