Neurogenic differentiation 2 promotes inflammatory activation of macrophages in doxorubicin-induced myocarditis via regulating protein kinase D

Abstract Background Although it has been established that protein kinase D (PKD) plays a crucial role in various diseases, its precise role in myocarditis remains elusive. Methods To investigate PKD’s involvement in myocarditis, we established a mouse model of myocarditis using doxorubicin (DOX) to...

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發表在:	BMC Cardiovascular Disorders
Main Authors:	Xinyu Tan, Changyu Yan, Gang Zou, Ran Jing
格式:	Article
語言:	英语
出版:	BMC 2025-03-01
主題:	Myocarditis NeuroD2 PKD Macrophages Inflammatory activation NLRP3/NF-κB pathway
在線閱讀:	https://doi.org/10.1186/s12872-025-04626-7