Regulation of anti-tumour effects of Paris polyphylla saponins via ROS: molecular mechanisms and therapeutic potentials

Reactive oxygen species (ROS) exhibit a dual regulatory role in cancer biology. While moderate ROS levels promote tumorigenesis via DNA mutagenesis, excessive ROS accumulation induces cancer cell death through oxidative stress. Therefore, ROS homeostasis represents a promising therapeutic target in...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Jia Liu, Yongping Mu, Ke Qi, Jiayi Li, Yang Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	Paris polyphylla reactive oxygen species anti-cancer mechanism saponins
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1611911/full