Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter

Cell differentiation programs require dynamic regulation of gene expression. During meiotic prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit Ndc80 is downregulated by a 5’ extended long undecoded NDC80 transcript isoform. Here we demonstrate a transcriptional inter...

Full description

Bibliographic Details

Published in:	eLife
Main Authors:	Minghao Chia, Amy Tresenrider, Jingxun Chen, Gianpiero Spedale, Victoria Jorgensen, Elçin Ünal, Folkert Jacobus van Werven
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-09-01
Subjects:	transcription chromatin meiosis interference mRNA isoform promoter
Online Access:	https://elifesciences.org/articles/27420