Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.

BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial channel protein VDAC2. VDAC2 is important for bringing both BAK...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Zheng Yuan, Mark F van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J Smith, David C S Huang, Guillaume Lessene, Yelena Khakam, Ruitao Jin, Sitong He, Nicholas A Smith, Richard W Birkinshaw, Peter E Czabotar, Grant Dewson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2024-05-01
Online Access:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002617&type=printable