Duloxetine and pregabalin: High-dose monotherapy or their combination?-Study protocol for a randomized trial in patients with postoperative pain after total knee arthroplasty based on the classification of central sensitization inventory scores.

<h4>Background</h4>Residual pain after total knee arthroplasty (TKA) often causes patient dissatisfaction. Patients with preoperative central sensitization (CS) are especially susceptible to chronic pain after TKA. Although duloxetine and pregabalin are known to relieve pain in CS patien...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Haodong Wu, Shuxin Yao, Yuanchi Huang, Chao Xu, Jianbing Ma
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0334400