Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut microbiota and its host. However, factors regulating AhR within the gut, which is a complex metabolomic environment, are poorly understood. This study investigates the effect of a combination of metabolites on the...

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Bibliographic Details

Published in:	Gut Microbes
Main Authors:	Morgane Modoux, Nathalie Rolhion, Jeremie H. Lefevre, Cyriane Oeuvray, Petr Nádvorník, Peter Illes, Patrick Emond, Yann Parc, Sridhar Mani, Zdenek Dvorak, Harry Sokol
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Subjects:	Microbiota AhR butyrate FICZ HDAC CYP1A1
Online Access:	https://www.tandfonline.com/doi/10.1080/19490976.2022.2105637