<i>IKZF1</i> Alterations and Therapeutic Targeting in B-Cell Acute Lymphoblastic Leukemia

<i>IKZF1</i> encodes the transcription factor IKAROS, a zinc finger DNA-binding protein with a key role in lymphoid lineage development. IKAROS plays a critical role in the development of lineage-restricted mature lymphocytes. Deletions within <i>IKZF1</i> in B-cell acute lym...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Biomedicines
المؤلفون الرئيسيون: Jonathan Paolino, Harrison K. Tsai, Marian H. Harris, Yana Pikman
التنسيق: مقال
اللغة:الإنجليزية
منشور في: MDPI AG 2024-01-01
الموضوعات:
<i>IKZF1</i>
IKAROS
B-cell acute lymphoblastic leukemia
الوصول للمادة أونلاين:https://www.mdpi.com/2227-9059/12/1/89
الوصف
الملخص:<i>IKZF1</i> encodes the transcription factor IKAROS, a zinc finger DNA-binding protein with a key role in lymphoid lineage development. IKAROS plays a critical role in the development of lineage-restricted mature lymphocytes. Deletions within <i>IKZF1</i> in B-cell acute lymphoblastic leukemia (B-ALL) lead to a loss of normal IKAROS function, conferring leukemic stem cell properties, including self-renewal and subsequent uncontrolled growth. <i>IKZF1</i> deletions are associated with treatment resistance and inferior outcomes. Early identification of <i>IKZF1</i> deletions in B-ALL may inform the intensification of therapy and other potential treatment strategies to improve outcomes in this high-risk leukemia.
تدمد:2227-9059

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