A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS

Neuronal cytoplasmic aggregation and ubiquitination of TDP-43 is the most common disease pathology linking Amyotrophic Lateral Sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 pathology is characterized by the presence of low molecular weight TDP-43 species generated through prot...

Full description

Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Marc Shenouda, Shangxi Xiao, Laura MacNair, Agnes Lau, Janice Robertson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	TARDBP TDP-43 amyotrophic lateral sclerosis frontotemporal lobar degeneration N-terminal fragment C-splice variant
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2022.868556/full